The presence of COVID-19 in 2019, precisely in March, opened new horizons in all parts of the world. It is a separate historical record that has shaken and worried about all social stratification, especially in Indonesia. As an impact, in the realm of education, the impact of the socio-economic impact of schools, for example at SMK Muhammadiyah 3 Yogyakarta, experienced a significant decrease in PPDB income. The purpose of this study is to find a student admission management model from a neuroscience perspective that has implications for the PPDB management of the Muhammadiyah 3 Yogyakarta vocational school during the COVID-19 period. This research is a Field Research (Field Study) with a qualitative descriptive approach. The data collection technique of this research is through the results of observations, interviews, and Documentation with the Principal, Deputy Head of Student Affairs, Deputy Head of Public Relations, Head of PPDB and prospective new students of SMK Muhamamdiyah 3 Yogyakarta. The data analysis technique used is fenemenology, namely the technique to draw conclusions based on the data obtained in accordance with the objectives of this study. The results of this study prove that the new student admissions management model with the Neuroscience approach is an alternative to schools during the COVID-19 pandemic. During the COVID-10 pandemic, the income of prospective students who previously had a percentage showed mines with such an income. Due to the socio-economic impact of COVID-19, and zoning of public schools. With that, the Muhammadiyah 3 Yogyakarta Vocational School responded with a Neuroscience approach in mid-2020 to date, giving optimism and social enthusiasm that affect the sensitivity of the dimensional brain (normal brain, healthy and smart) towards prospective new students and parents. Thus, gradually, Muhammadiyah 3 Yogyakarta Vocational High School has experienced an increase in PPDB and the welfare of employee teachers, which has implications for the social and educational aspects of the COVID-19 period.