Abstract: Hypertension is a condition where there is an abnormal increase in blood pressure which can be the main cause of cardiovascular disease. Hypertension stimulates the formation of free radicals called reactive oxygen species (ROS) and oxidative stress. Manggo parasite (Dendropthoe pentandra) can reduce oxidative stress in the lung tissue of hypertensive rats. This study aims to further examine the role of Dendropthoe pentandra as a modulator of endogenous antioxidants, in this case superoxide dismutase (SOD) in lung tissue of hypertensive rats. The research method used is experimental method. Data were analyzed using oneway ANOVA and Post Hoc tests to see differences in SOD levels in various treatments. This study used a rat model of hypertension induced by deoxycorticosterone acetate (DOCA) and salt. The number of tested animals was 30 male white rats divided into 6 groups, each group containing 5 rats. The group consisted of negative control, positive control, negative control at the dose of 50 mg / kg BW, the treatment group for parasite tea with doses of 50, 100, and 200 mg / kg BW. Based on the results of the study, it was known that the levels of increased lung SOD with BM dosing in all treatment groups were significantly different (p <0.001). The administration of mango parasite extract at a dose of 50 mg / kg BW is optimum and has the same potential as the 100 mg / kg BW dose treatment in increasing lung SOD levels in hypertensive rats.

Key words: Benalu tea, SOD levels, hypertensive rats, DOCA-salt