STUDI PUSTAKA SISTEMATIS:

PENGARUH DELIMA TERHADAP SUPEROXIDE DISMUTASE DAN MALONDIALDEHYDE DALAM KONDISI STRES OKSIDATIF

Dewi Intan Putri Dwiyanti¹ , Fifin Pradina Duhitatrissari¹, Doti Wahyuningsih¹*

¹Program Studi Pendidikan Dokter, Universitas Islam Malang, JL. MT. Haryono 193, Malang, Jawa Timur, Indonesia

*dotiwahyuningsih@unisma.ac.id

Abstract: Oxidative stress is a condition when there is an imbalance between the amount of free radical and  antioxidant. Pomegranate (Punica Granatum L.) was reported as scavenger for free radical, so it could reduce oxidative stress. the aim of this systematic literature review is proving the research result about pomegranate's efficacy in resolving oxidative stress by checking the SOD and MDA level. oxidative stress condition in this literature study includes intoxicity of certain disease, diabetes mellitus, neurodegenerative disease, and pollutant. Extract types that will be studied are skin, fruit, flower, leaf, seed, and juice of pomegranate. Systematic Literature Review. Data was collected from PubMed Central, PubMed, and Google Scholar according to the pomegranate or Punica granatum, oxidative stress, SOD, and MDA as keywords. The screening process results 100 relevant articles, and 17 of them were qualified for the inclusion criteria chosen to be reviewed. The peel, seed, flower, leaf, and juice of pomegranate extract could increase SOD level and decrease MDA. So pomegranate extract could increase the SOD level and decrease the MDA level.

Keywords: Pomegranate, Stress Oxidative, SOD and MDA

Abstrak: Stres Oksidatif adalah keadaan ketidakseimbangan antara jumlah radikal bebas dan antioksidan. Delima (Punica Granatum L.) dilaporkan berperan sebagai scavenger bagi radikal bebas, sehingga dapat mengurangi stres oksidatif. Tujuan dari penelitian studi pustaka sistematis ini adalah untuk membuktikan hasil riset tentang kegunaan buah delima dalam mengatasi stres oksidatif dengan memeriksa kadar SOD dan MDA. Kondisi stres oksidatif dalam studi literature ini meliputi intoksisikasi karena penggunaan obat tertentu, diabetes militus, penyakit neurodegenerative dan polutan. Jenis ekstrak yang akan dipelajari adalah ekstark kulit, buah, bunga, daun, biji dan jus buah delima. Systematic Literature Review. Data penelitian dikumpulkan dari PubMed Central, PubMed, dan Google Scholar berdasarkan kata kunci pomegranate, stres oksidatif, SOD, dan MDA. Proses screening menghasilkan 100 artikel yang relevan. Yang memenuhi kriteria inklusi untuk ditelaah berjumlah 17 artikel. Ekstrak kulit, biji, bunga, daun, serta jus buah delima mampu menaikkan kadar SOD dan menurunkan kadar MDA. Jadi ekstrak dari delima mampu menaikkan kadar SOD dan menurunkan kadar MDA

Kata kunci: Delima, stres oksidatif, SOD dan MDA