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STUDI PUSTAKA SISTEMATIS:

PENGARUH KURKUMIN SEBAGAI ANTIINFLAMASI TERHADAP C-REACTIVE PROTEIN PADA BERBAGAI PENYAKIT INFLAMASI

Andrie Devin Susilo Hadi¹, Marindra Firmansyah¹, Doti Wahyuningsih^1*

¹Program Studi Pendidikan Dokter, Universitas Islam Malang, JL. MT. Haryono 193, Malang, Jawa Timur, Indonesia

*dotiwahyuningsih@unisma.ac.id

Abstract: C-Reactive Protein (CRP) is protein produced in acute phase of inflammatory conditions which until now has been used as a clinical systemic marker. Curcumin was reported to have anti-inflammatory effects. This systematic literature study was conducted to learn the effect of curcumin on decreasing CRP levels in pathophysiological disorders implicate inflammation. This work studies the effect of curcumin to CRP levels in : metabolism, malignancy, infection, and intoxication. Systematic literature study. Data were collected from PubMed and Google Scholar based on the keywords Curcumin, C-Reactive Protein, and Inflamation. The screening process resulted in 16 articles that met the inclusion criteria set for review. Curcumin was shown to be able to reduce CRP levels in inflammatory conditions. This study reports Curcumin works by inhibit pro-inflammatory cytokines Tumor Necrosis Factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6) as well as inhibit the activation of transcription factor Nuclear Factor-Kappa B (NF-κB). That curcumin was able to reduce CRP levels in inflammatory conditions.Keyword: Curcumin, C-Reactive Protein, inflamation

Abstract: C-Reactive Protein (CRP) merupakan protein yang dihasilkan pada fase akut dari kondisi inflamasi yang sampai sekarang digunakan sebagai penanda sistemik di klinis. Kurkumin dilaporkan memiliki pengaruh sebagai antiinflamasi. Studi Pustaka sistematis ini dilakukan untuk mempelajari pengaruh kurkumin terhadap penurunan kadar CRP pada berbagai kelainan yang patofisiologinya melibatkan inflamasi. Pada studi ini dipelajari pengaruh kurkumin pada CRP dari kelainan: metabolisme, keganasan, infeksi,dan intoksikasi. Studi Pustaka sistematis. Data dikumpulkan dari PubMed dan Google Scholar berdasarkan kata kunci Curcumin, C-Reactive Protein, dan Inflamation. Proses screening menghasilkan 16 artikel yang memenuhi kriteria inklusi yang ditetapkan untuk ditelaah. Kurkumin terbukti mampu menurunkan kadar CRP pada berbagai kondisi inflamasi. Dalam penelitian ini dilaporkan Kurkumin bekerja dengan menghambat Tumor Necrosis Factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6) serta menghambat aktivasi faktor transkripsi Nuclear Factor-Kappa B (NF-κB). Sehingga kurkumin mampu menurunkan kadar CRP pada berbagai kondisi inflamasi.

Kata Kunci : Kurkumin, C-Reactive Protein, Inflamas