Islam as the most perfect religion not only regulates the human relationship with God, but also regulates human relationships with fellow human beings and the universe. This is partly seen in the vision, mission and purpose of Islamic teachings which in essence raise the dignity of human beings and all other creatures, except syaithan, Satan or those who deny it. The relationship of Islam to culture and science is seen in the instruction of Islam in order to utilize the physical potential, the five senses, the mind and conscience in utilizing all the gifts of Allah SWT, travel in advance, explore the knowledge, experience and so on, to realize the happiness of the world and the Hereafter. We as human beings, can not be separated from our responsibility as the Caliph on earth. Where we are assigned to keep the earth and all its contents in order to remain beautiful. There is a reason why Allah created us as khalifah on this earth, that is because human beings have reason to think and recognize their environment. This is what distinguishes human beings from other living beings. Even the angels had protested because Adam has a position as khalifah. As Allah says in His word Q.S. Al-Baqarah: 34 "And remember when we said to angels: Thou shalt bow to Adam! So they bowed down, except the devil was reluctant and boasted, for he was of the disbelieving creatures. " This writing uses literature review methods are processed from some official sources of the Qur'an, Journal, Articles and Books so that the exposure is done based on libraries that have been done by the author.